Organophosphorus pesticide poisoning in dogs and cats
Organophosphorus pesticide poisoning in dogs and cats
Dogs and cats licking food that has been exposed to organophosphorus pesticides or inhalation of organophosphorus pesticides will cause poisoning phenomenon, canine and cat organophosphorus pesticide poisoning will appear panting, drooling, vomiting, fecal and urinary incontinence, convulsions and spasms, etc., and do not discharge the toxin in time will lead to respiratory distress and death.
Clinical symptoms of organophosphorus pesticide poisoning in dogs and cats
Organophosphorus pesticides is a general term for a class of agricultural pesticides synthesized from phosphorus and organic compounds, belonging to the intense contact poison, which can enter the cat’s organism through the digestive tract, respiratory tract and skin, and combine with the body cholinesterase enzyme, so that it loses the role of hydrolysis of acetylcholine, leading to the accumulation of acetylcholine in the body, which leads to a series of neurophysiological dysfunctions.
The severity of poisoning is influenced by the route of entry of the poison into the body, and symptoms of poisoning most often appear within a few hours after the poison enters the body. Acute poisoning is characterized by respiratory distress, respiratory failure and finally death from respiratory paralysis. It is clinically categorized into three types of syndromes:
1. Muscarinic symptoms: increased salivation, salivation, vomiting, diarrhea, frequent urination, urinary incontinence, pupil constriction, increased bronchial secretion, respiratory distress.
2. Nicotine-like symptoms: muscle weakness or spontaneous contraction, twitching of facial muscles and tongue muscles, which then spreads to the whole body’s muscle tissues and paralysis.
3. Central nervous system symptoms: extreme depression or euphoria, dyskinesia, panic, convulsion-like symptoms.
Dr. Oxygen Pet recommends
1, dogs and cats organophosphorus pesticide poisoning need to wash the stomach as soon as possible, vomiting, to minimize the residue in the body, taking special drugs for treatment, first a lot of water to rinse the mouth or skin, and then quickly sent to the hospital again.
2. After resuscitation, dogs and cats may have different degrees of pulmonary edema, liver damage, gastrointestinal mucosal damage, and need follow-up convalescence for recovery.
① Oral hydrochlorothiazide tablets, diuretic and catheterization, for the treatment of pulmonary effusion in pets, 3-4 mg/kg body weight, should not be taken for too long.
② Bile acid liver protection tablets, help liver detoxification and anti-toxicity, promote liver synthesis of complement proteins, once/day for 15 days~3 months.
(iii) Oral administration of Velic Basic Bismuth Carbonate Tablets to help pets repair intestinal mucosa, once a day, according to body weight.
④ Use Pet Electrolyte Concentrate to accelerate the efficiency of recovery after functional damage, administered orally ad libitum for 3-5 days.
Treatment Options for Organophosphorus Pesticide Poisoning in Dogs and Cats
The principle of treatment is based on cutting off the source of poison, preventing or delaying the body’s absorption of the poison, discharging the poison, applying special antidotes and symptomatic treatment.
Cut off the source of the poison. Immediately stop any further ingestion of or exposure to the poison.
Poisoning caused by skin contact, clean water can be used to fully rinse the hair and skin of the contact area of the cat to avoid continued absorption and aggravation of the condition.
Poisoning caused by oral intake, not more than 2 hours can be used to induce vomiting or gastric lavage, at the same time with the adsorbent to promote the elimination of poison.
1. 0.2%~0.5% copper sulfate (emetic), dogs: 0.1~0.5g/dose orally, cats: 0.05~0.1g/dose, orally.
2. 1% zinc sulfate (emetic), 0.2~0.4 g/dose, orally.
3. 0.1%~0.2% potassium permanganate gastric lavage. 20~50 ml enema gastric lavage.
4. Activated charcoal (to adsorb organophosphorus insecticides so that they are discharged from the feces), 3-6 g/kg, orally.
5. Atropine sulfate (blocks muscarinic symptoms of acetylcholine), 0.2-0.5 mg/kg; 1/4 intravenously, the rest subcutaneously/intramuscularly.
6. Chlorophosphamide (special antidote), 20 mg/kg, intravenous drip/intramuscular injection, twice a day.
7, Iodophosphatidine (special antidote), 20 mg / kg, intravenous drip, twice a day, to the reduction of symptoms.
8. Difenphos (special antidote), 15-30 mg/kg, intravenous drip, twice a day, until the symptoms are reduced. Double phosphorus on acute poisoning of endophosphorus, parathion, methidophos and other poisoning of the efficacy of good, but the effect of chronic poisoning is not good.
9, bisphosphonate (special antidote), 15-30 mg / kg, intravenous drip, twice a day, to the reduction of symptoms.
Vomiting and diarrhea are severe enough to require intravenous fluid therapy.
Enhance the liver detoxification function, use liver-protecting drugs, moderate intravenous infusion of glucose solution, vitamin C, hepatic tylenol and so on.
Intravenous hypertonic glucose solution when pulmonary edema occurs.
When respiratory failure occurs, move the dog or cat to a ventilated area and administer oxygen.
Give antibiotics, sedatives, cardiac stimulants, respiratory stimulants, etc.
Contraindications: Morphine, succinylcholine, phenothiazine, Valium, epinephrine and other drugs are contraindicated.